Buffers & Reagents for Life Sciences & Molecular Diagnostics
At ReAgent, we manufacture biological buffers and reagents for use in life science laboratories and in vitro diagnostics kits. Products we supply include buffers for medical devices which are used in cancer diagnosis, and diagnostic test kits used in a saliva based testing kit for COVID-19. We also supply reagent buffers for use in antibody testing and DNA sample preparation.
All of our buffers and reagents are manufactured using chemicals that are approved for their intended use, and full change control and notification processes are in place. All products are also subject to extensive quality checks.
Additionally, we are able to pack your buffers and reagents in sterile, DNAse and RNAse-free packaging, and manufacture products in ISO Class 7 cleanroom conditions. Products are routinely filtered to 0.2µ during the packing process.
Do you need bespoke biological buffers? At ReAgent, we manufacture and supply high-quality buffers to meet your exact needs. We can work with you to create a new formulation, or we can support you in making changes to existing formulations. Whatever your unique requirements, you can feel confident that you will receive a high-quality product and outstanding customer service from an expert biological buffer manufacturer. Just some of the biological buffers we can manufacture include:
Bis-tris is a protein and nucleic acid buffer used in molecular biology and biochemistry. It is best for a pH range of 5.8-7.2 and acts as a substitute for cacodylate, a highly toxic buffer.
HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) is a zwitterionic sulphonic acid buffer, and is one of the twenty Good’s buffers. HEPES is commonly used in cell culture.
PIPES (piperazine-N,N′-bis(2-ethanesulfonic acid)) is another of the Good’s buffers and is typically used in biochemistry.
Phosphate-Buffered Saline (PBS)
Phosphate-buffered saline (PBS) is a water-based salt solution frequently used in biological research for two reasons. Firstly, this buffer helps to sustain a constant pH, and secondly, the ion concentrations match the human body. As an added-value service from ReAgent, we are able to have PBS sterilised by gamma radiation post-packing. This extends the shelf-life of the buffer and provides a better quality product.
Tris (tris(hydroxymethyl)aminomethane), is widely used in molecular biology and biochemistry. It has a pH range of between 7.1 and 9.1 at room temperature, which matches the physiological pH common to most living organisms.
Tris Hydrochloride (Tris HCl) Buffer
Tri HCl is used in pharmaceutical and biopharmaceutical production and is suitable for cell culture. It is very water-soluble and is useful in the 7.0-9.0 pH range.
ReAgent can manufacture a range of high-quality bioprocessing reagents and supply them in a variety of sizes up to 1,000 litres. They can be filled, packed into bioprocessing containers, and labelled ready for your use. We will work with you to create the formulation and solution that’s right for your unique bioprocessing needs.
In Vitro Diagnostic (IVD) Reagents
ReAgent is an ISO 13485 accredited, flexible manufacturer of bespoke in vitro diagnostic reagents for use with medical devices. The products we supply provide consistent, reliable results and meet stringent IVD requirements.
What Are In Vitro Diagnostic Reagents?
Good healthcare depends on the biological and clinical analysis of samples which provide consistently accurate diagnoses. Most of the medical devices which perform these analyses require in vitro diagnostic reagents to deliver accurate results, enabling healthcare providers to dispense targeted treatment plans.
Why IVD Reagents Are So Important
The analysis of saliva, blood, tissue, and other bodily fluids provides doctors with the critical information they need to give a medical diagnosis. It’s often the case that the medical devices which produce the results run continuously to meet service demand, so consistent reliability and accuracy of analysis is crucially important.
The efficient, high-quality manufacture, handling, and delivery of in vitro diagnostic reagents can therefore assist in reducing costs incurred through equipment downtime and improve service demand.
Quality Assurance with ISO 13485 Accreditation for Medical Devices
ReAgent is accredited to ISO 13485 (Medical devices – Quality management systems – Requirements), demonstrating that we adhere to the stringent requirements of a quality management system specific to the medical devices industry. We meet the current Medical Device Directives, regulations, and responsibilities, and are committed to the safety and quality of the IVD reagents we supply for medical devices.
Our customers benefit from this accreditation with:
- Peace of mind that we have manufacturing processes and controls suitable for chemical products used in medical devices
- More time to focus on the bespoke IVD reagent you need, rather than on systems and processes
- The ability to provide confidence and quality assurance to the end user
- The immediate understanding that ReAgent is a credible, trustworthy manufacturer of bespoke IVD reagents
ReAgent’s Quality Standards
We source raw materials from around the world, but all our biological reagent manufacturing is done in our large facility in Cheshire, UK. This is so we can be sure our products meet the rigorous ISO 9001:2008 Quality Standard and our ISO 14001:2004 Environmental Standard, as well as the standards for ISO 13485. This also means that we can provide our customers with a faster turnaround time and better value for money.
We also use a LEAN way of working and continually look to improve. We use the most efficient techniques available, can expand our services to meet your requirements, and ensure on-time delivery. We also provide end-to-end support, from pre-sales technical advice to managing inventory and the supply chain.
A Collaborative Approach
ReAgent is a customer-led business, and you’ll find that we can be flexible and adapt to meet your requirements, whatever your industry. This might mean developing new manufacturing techniques, investing in new equipment, or undertaking training. You may also need us to adopt industry-specific systems to meet required standards, which we are happy to do.
Whatever the requirement, we’ll work closely with you to supply the biological reagent you need, in the volume you need, at the time you need it. Our expert technical team is also on-hand to provide their advice and expertise. This collaborative approach and adaptability are just two of the reasons we have a strong reputation as a high-quality chemical and contract manufacturer in the UK.